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October 29 2010
Data against CCSVI role in ms, Multiple Sclerosis, #multiplesclerosis, #ppms,, primary progressive Multiple Sclerosis,
Data against CCSVI role in MS
Although the Zamboni papers have been quite supportive of CCSVI, there are a growing number of papers that raise serious questions about its validity. In early 2010, Khan et al described a number of independently accepted characteristics of venous disease and MS that contradict the CCSVI theory.6
1.
Similar to other autoimmune diseases, MS is more common in young women while chronic venous insufficiency syndromes are not.
2.There are well known strong epidemiological associations between MS and geography, ethnicity, sun exposure, low vitamin D levels, gender, genetics and immigration studies that are not mirrored by chronic venous insufficiency.
3.Central veno-occlusive disease can lead to syndromes of idiopathic intracranial hypertension, ischemic and hemorrhagic infarcts and edema, none of which is typically seen in MS patients.
4.Vascular abnormalities related to chronically diminished venous flow would be expected to increase over time, yet after the age of 50 years the incidence of MS is quite low.
5.There is no other model of decreased venous drainage and an organ specific immune response.
6.Transient global ischemia is known to occur with jugular insufficiency but this entity is not seen in MS.
7.Radical neck dissections remove all jugular veins but they have never been seen to cause MS.6
